Fe2+ activating persulfate selectively oxidized alcohols by biphasic/homogeneous reaction switch strategy was written by Wang, Junyan;Liu, Xiaona;Wang, Xing;Yin, Hailiang;Guo, Qingbin;Liu, Di. And the article was included in Chemical Papers in 2022.COA of Formula: C7H7ClO This article mentions the following:
A facile and efficient oxidation of alc. by Fe2+ activating persulfate was performed and a homogeneous/biphasic reaction switch strategy was proposed to regulate the oxidation process. Na2S2O8 and FeSO4 were employed as the oxidant and the source of activator Fe(II), resp. Fe2+ efficiently excited persulfate, endowing persulfate with powerful oxidation activity. Benefited from this, the oxidation of benzylic primary alcs. and cyclic secondary alcs. could proceed to give the corresponding aldehydes or ketones with good yields (85.2-98.5%) under the optimal conditions of 60°C, 1.5 mol equivalent Na2S2O8 and 0.3 mol equivalent Fe2+ to substrate in a water/dichloroethane biphase system. Moreover, the primary alcs. were one-step oxidized into carboxylic acids with high selectivity by raising reaction temperature, increasing the amount of oxidant and switching from biphasic reaction to the water/MeCN homogeneous phase. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7COA of Formula: C7H7ClO).
(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C7H7ClO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts