SN2 Reaction of sulfur nucleophiles with hindered sulfamidates: Enantioselective synthesis of α-methylisocysteine was written by Avenoza, Alberto;Busto, Jesus H.;Jimenez-Oses, Gonzalo;Peregrina, Jesus M.. And the article was included in Journal of Organic Chemistry in 2006.Recommanded Product: 29364-29-2 This article mentions the following:
The work described here demonstrates that the five-membered cyclic α-methylisoserine-derived sulfamidate (I) behaves as an excellent chiral building block for the ring-opening reaction by SN2 attack with sulfur nucleophiles at the quaternary carbon. As a synthetic application of this methodol., and to show that this sulfamidate is a valuable starting material, the synthesis of two new α-methylisocysteine derivatives has been carried out to cover the lack of α- and β-methylated amino acids that incorporate the cysteine or isocysteine skeleton. These compounds are two new α,α-disubstituted β-amino acids (β2,2-amino acids), and the synthetic routes involve nucleophilic ring opening followed by acid hydrolysis. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Recommanded Product: 29364-29-2).
Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 29364-29-2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts