Souers, Andrew J. published the artcileSynthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1, Computed Properties of 2240-88-2, the publication is Bioorganic & Medicinal Chemistry Letters (2004), 14(19), 4873-4877, database is CAplus and MEDLINE.
A high-throughput screen was performed in order to identify compounds that were bound by the melanin concentrating hormone receptor-1. 2-Amino-8-(cyclohexylmethyloxy)quinoline was identified and subsequently optimized using a parallel and automated procedure for the rapid production of multiple analogs. The structure-activity relationships that emerged from this effort are described, along with selected pharmacokinetic parameters of (d)-I when dosed orally in diet-induced obese mice.
Bioorganic & Medicinal Chemistry Letters published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C12H13F2N3O4S, Computed Properties of 2240-88-2.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
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