Peng, Fang-liang published the artcileClinical observation of carboprost tromethamine and oxytocin in the treatment of postpartum hemorrhage, Application In Synthesis of 58551-69-2, the publication is Zhongguo Yaofang (2014), 25(32), 3015-3017, database is CAplus.
This paper is to observe clin. efficacy and safety of carboprost tromethamine and oxytocin in the treatment of postpartum hemorrhage. 60 Delivery women with postpartum hemorrhage were randomly divided into control group and observation group. In control group, women undergoing natural labor were given i.m. injection of oxytocin 20 u after delivery of fetus, and women undergoing caesarean section were given intrauterine injection of oxytocin 20 u after delivery of fetus; then all of them received i.v. dripping of oxytocin 20 u added into 5% glucose solution 500 mL, and i.v. injection of oxytocin was given repeatedly and oral dose of misoprostol was given 600 mg if necessary, qd. Observation group was addnl. given intrauterine injection of carboprost tromethamine 0.25 mg on the basis of control group, and repeated injection was given if necessary; total daily dose could not be more than 2.0 mg and medication interval was more than 15 min. The clin. efficacy, the intensity of uterine contraction, hemostatic rates of patients with different amount of bleeding at different time and ADR were observed in 2 groups. The total effective rate, the intensity of uterine contraction hemostatic rates of patients with different amount of bleeding 5, 10 and 15 min after medication in observation group were significantly higher than those in control group, and there were statistical significances(P<0.05); there was no statistical significance in the incidence of ADR between 2 groups(P>0.05). Carboprost tromethamine and oxytocin are more effective and safer than oxytocin alone in the treatment of postpartum hemorrhage.
Zhongguo Yaofang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application In Synthesis of 58551-69-2.
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