Itoga, Moeko published the artcileIridium-catalyzed α-selective deuteration of alcohols, Computed Properties of 111-29-5, the publication is Chemical Science (2022), 13(30), 8744-8751, database is CAplus and MEDLINE.
The α-selective, iridium(III)-bipyridonate-catalyzed hydrogen(H)/deuterium(D) isotope exchange of alcs. using deuterium oxide (D2O) as the primary deuterium source to afford deuterated alcs. RCD2OH [R = Ph, 2-MeC6H4, 4-FC6H4, etc.], R1DCOHR2 [R1 = Ph, 4-ClC6H4, 4-BrC6H4, etc.; R2 = Me, cyclopropyl, Ph] was reported. This method enabled the direct, chemoselective deuteration of primary and secondary alcs. under basic or neutral conditions without being affected by coordinative functional groups such as imidazole and tetrazole. Successful substrates for deuterium labeling include the pharmaceuticals losartan potassium, rapidosept, guaifenesin and diprophylline. The deuterated losartan potassium showedhigher stability toward the metabolism by CYP2C9 than the protiated analog. Kinetic and DFT studies indicated that the direct deuteration proceeded through dehydrogenation of alc. to the carbonyl intermediate, conversion of [IrIII-H] to [IrIII-D] with D2O, and deuteration of the carbonyl intermediate to give the α-deuterated products.
Chemical Science published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Computed Properties of 111-29-5.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts