Elslager, Edward F. published the artcileSynthetic schistosomicides. XVI. 5-(Mono- and dialkylamino)-2-nitrosophenols, 2-amino-5-(dialkylamino)phenols, and related compounds, Formula: C10H13NO2, the publication is Journal of Medicinal Chemistry (1970), 13(3), 370-6, database is CAplus and MEDLINE.
Various 5-(mono- and dialkylamino)-2-nitrosophenols were prepared by nitrosation of the corresponding m-(mono- and dialkylamino)phenols, obtained by heating resorcinol with an excess of the appropriate amine at 200°, or by alkylation of m-aminophenol with an alkyl halide. 5-(Dimethylamino)-2-nitrosophenol, 5-(diethylamino)-2-nitrosophenol (I), 2-nitroso-5-(1-pyrrolidinyl)phenol, and 2-amino-5-(diethylamino)phenol, a potential metabolite of I, displayed strong schistosomicidal activity and effected a 70-100% reduction of adult Schistosoma mansoni in mice at daily doses of 177-568 mg/kg for 14 days. Structure-activity relationship are summarized, and information concerning potential metabolites and the possible mode of action of the nitrosophenols is discussed.
Journal of Medicinal Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Formula: C10H13NO2.
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