Heffernan, Michele L. R. published the artcileUlotaront: A TAAR1 Agonist for the Treatment of Schizophrenia, COA of Formula: C4H11NO2, the main research area is structure TAAR1 agonist ulotaront preparation schizophrenia.
Ulotaront (SEP-363856) is a trace-amine associated receptor 1 (TAAR1) agonist with 5-HT1A receptor agonist activity in Phase 3 clin. development, with FDA Breakthrough Therapy Designation, for the treatment of schizophrenia. TAAR1 is a G-protein-coupled receptor (GPCR) that is expressed in cortical, limbic, and midbrain monoaminergic regions. It is activated by endogenous trace amines, and is believed to play an important role in modulating dopaminergic, serotonergic, and glutamatergic circuitry. TAAR1 agonism data are reported herein for ulotaront and its analogs in comparison to endogenous TAAR1 agonists. In addition, a human TAAR1 homol. model was built around ulotaront to identify key interactions and attempt to better understand the scaffold-specific TAAR1 agonism structure-activity relationships.
ACS Medicinal Chemistry Letters published new progress about Antipsychotics. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, COA of Formula: C4H11NO2.
Referemce:
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Alcohols – Chemistry LibreTexts