Hansen, Moritz E. published the artcileTotal synthesis of mutanobactins A, B from the human microbiome: Macrocyclization and thiazepanone assembly in a single step, Related Products of alcohols-buliding-blocks, the main research area is mutanobactin total synthesis human microbiome lipopeptide; aspartate substitution reduction Mutsunobu displacement phthalimide methanolysis cyclization; peptide coupling solid phase synthesis macrocyclization thiazepanone assembly; cyclization mechanism dehydration aldol addition; Cyclization; Macrocycles; Peptide Synthesis; Total Synthesis.
We report the first total syntheses of tricyclic mutanobactins A and B, lipopeptides incorporating a thiazepanone, isolated from Streptococcus mutans, a member of the human oral microbiome. A rapid, solid-phase peptide synthesis (SPPS) based route delivers these natural products from a cascade of cyclization reactions. This versatile process was also employed in a streamlined synthesis of mutanobactin D. Addnl., we provide an independent synthesis of a truncated mutanobactin A analog, utilizing a novel thiazepanone amino acid building block.
Angewandte Chemie, International Edition published new progress about Aldol addition. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Related Products of alcohols-buliding-blocks.
Referemce:
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