Goodyer, Larry published the artcileCharacterisation of actions of p-menthane-3,8-diol repellent formulations against Aedes aegypti mosquitoes, Formula: C10H20O2, the main research area is menthane Aedes aegypti repellent formulation; DEET; PMD; half-life; longevity; mosquito; repellent.
Characterization of mosquito repellents using arm-in-cage tests are performed by assessing the 95% ED (ED95), half-life and complete protection time (CPT). This study fully characterizes these properties for p-menthane-3,8-diol (PMD), which has not been widely studied, and a long-acting formulation containing a PMD-vanillin composite. A series of arm-in-cage tests against Aedes aegypti (Diptera: Culicidae) mosquitoes were devised using 6 volunteers to estimate CPT or 10 to estimate the ED95 and half-lives for three repellents: 20% N,N-diethyl-3-methylbenzamide (DEET), 30% PMD and a novel 30% PMD-vanillin formulation. Non-linear regression anal. was used to characterize the relationship between applied dose and CPT. PMD and DEET showed a very similar log dose relationship to CPT; however, the PMD-vanillin formulation exhibited a sigmoidal ′S-shaped′ relationship. This resulted in a 1.5-fold higher CPT for PMD-vanillin compared with that of 20% DEET when applied at a dose of 1.6 mg/cm2, but little difference was observed at lower doses of 0.8-1 mg/cm2. The ED95 value for the 30% PMD and PMD-vanillin formulations were 0.25 and 0.24 mg/cm2, resp., these being higher than that for 20% DEET (0.09 mg/cm2). The half-lives for 30% PMD and 20% DEET were similar (2.23 vs. 2.74 h), but longer for the PMD-vanillin formulations (3.8 h). A full characterization for other repellent formulations, particularly those claiming extended longevity, should be conducted in order to identify differences at various applied doses.
Transactions of the Royal Society of Tropical Medicine and Hygiene published new progress about Aedes aegypti. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Formula: C10H20O2.
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