Frankowski, Kevin J. published the artcileDiscovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis, Application of 4,4-Diethoxybutan-1-amine, the publication is Journal of Medicinal Chemistry (2022), 65(12), 8303-8331, database is CAplus and MEDLINE.
A high-throughput, high-content assay was developed to identify novel small mols. that selectively reduce PNC prevalence in cancer cells. The pyrrolopyrimidine series able to reduce PNC prevalence in PC3M cancer cells at submicromolar concentrations without affecting cell viability was identified and further optimized. Structure-activity relationship exploration of the structural elements necessary for activity resulted in the discovery of several potent compounds Anal. of in vitro drug-like properties led to the discovery of the bioavailable analog, metarrestin, which has shown potent antimetastatic activity with improved survival in rodent models and is currently being evaluated in a first-in-human phase 1 clin. trial.
Journal of Medicinal Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Application of 4,4-Diethoxybutan-1-amine.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts