Bleehen, S. S.’s team published research in Journal of Investigative Dermatology in 50 | CAS: 1139-46-4

Journal of Investigative Dermatology published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Computed Properties of 1139-46-4.

Bleehen, S. S. published the artcileDepigmentation of skin with 4-sisopropylcatechol, mercaptoamines, and other compounds, Computed Properties of 1139-46-4, the publication is Journal of Investigative Dermatology (1968), 50(2), 103-17, database is CAplus and MEDLINE.

Thirty-three compounds including thiols, mercaptoamines, catechol, catechol derivatives, and quinones were tested for their depigmenting potency and irritant effect on the skin of guinea pigs. These compounds, in concentrations ranging from 1 to 10%, were applied topically to the epilated skin of the back and the unepilated skin of the ear of black guinea pigs; 4-isopropylcatechol (4-IPC) was the most potent depigmenting agent, and the depigmentation occurred only in the treated areas. When used in low concentrations (1-3%), 4-IPC did not irritate the skin. Evidence obtained by light and electron microscopy indicated that 4-IPC markedly reduced the population of the melanocytes in the epidermis. The few remaining melanocytes were rendered degenerative, and those found had only a few melanized melanosomes. Cutaneous depigmentation by 4-IPC apparently results from a selective action on melanocytes; they are either destroyed or inactivated.

Journal of Investigative Dermatology published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Computed Properties of 1139-46-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts