Yong, Jianping published the artcileSynthesis of isoxazole moiety containing ferrocene derivatives and preliminarily in vitro anticancer activity, Related Products of alcohols-buliding-blocks, the publication is MedChemComm (2014), 5(7), 968-972, database is CAplus.
Seven isoxazole-ring-containing ferrocene derivatives were synthesized and characterized by 1H NMR, 13C NMR, ESI-MS. Subsequently, their in vitro anticancer activity against A549, HCT116, and MCF-7 cell lines was preliminarily evaluated using the MTT method. Among them, ferrocenecarboxylic acid 3-(2-chlorophenyl)isoxazol-5-ylmethyl ester (3d) exhibited wide spectrum anticancer activity and is the most potent among the isoxazole-ring-containing ferrocene derivatives Compound 3d is more active against A549 and HCT116 cell lines (IC50s: 0.747 and 3.65 nM, resp.) than the reference drug gefitinib (IC50s: 17.90 and 21.55 μM, resp.). 3D can be seen as the best candidate for development of anticancer drugs.
MedChemComm published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Related Products of alcohols-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
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