Kong, Xu-Dong published the artcileA Smart Library of Epoxide Hydrolase Variants and the Top Hits for Synthesis of (S)-β-Blocker Precursors, Name: 4-Morpholino-1,2,5-thiadiazol-3-ol, the publication is Angewandte Chemie, International Edition (2014), 53(26), 6641-6644, database is CAplus and MEDLINE.
Microtuning of the enzyme active pocket has led to a smart library of epoxide hydrolase variants with an expanded substrate spectrum covering a series of typical β-blocker precursors. Improved activities of 6- to 430-fold were achieved by redesigning the active site at two predicted hot spots. This study represents a breakthrough in protein engineering of epoxide hydrolases and resulted in enhanced activity toward bulky substrates.
Angewandte Chemie, International Edition published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, Name: 4-Morpholino-1,2,5-thiadiazol-3-ol.
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