Zhang, Hong published the artcileCytotoxicity and degradation product identification of thermally treated ceftiofur, Name: 2,2-Dimethoxyethanamine, the main research area is ceftiofur cytotoxicity thermal treatment cell proliferation.
Ceftiofur (CEF) is a cephalosporin antibiotic and is a commonly used drug in animal food production As a heat-labile compound, the residual CEF toxicity after thermal treatment has rarely been reported. This study was to investigate the potential toxicity of thermally treated CEF and determine the toxic components. By cytotoxicity tests and liquid chromatog.-mass spectrometry (LC-MS) assays, the cytotoxicity of the thermally treated CEF (TTC) and the components of TTC was identified, resp. Our results showed that TTC exhibited significantly increased toxicity compared with CEF towards LO2 cells by inducing apoptosis. Through LC-MS assays, we identified that the toxic compound of TTC was CEF-aldehyde (CEF-1). The IC50 value of CEF-1 on LO2 cells treated for 24 h was 573.1μg mL-1, approx. 5.3 times lower than CEF (3052.0μg mL-1) and 3.4 times lower than TTC (1967.0μg mL-1). Moreover, we found that CEF-1 was also present in thermally treated desfuroylceftiofur (DFC), the primary metabolite of CEF, indicating that residual CEF or DFC could produce CEF-1 during the heating process. These findings suggest that CEF-1 is a newly identified toxic compound, and CEF-1 may pose a potential threat to food safety or public health.
RSC Advances published new progress about Apoptosis. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Name: 2,2-Dimethoxyethanamine.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts