Guo, Chuangxing published the artcileDiscovery of 3-aryloxy-lactam analogs as potent androgen receptor full antagonists for treating castration resistant prostate cancer, COA of Formula: C4H9BrO, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(2), 1230-1236, database is CAplus and MEDLINE.
High throughput cell-based screening led to the identification of 3-aryloxy lactams as potent androgen receptor (AR) antagonists. Refinement of these leads to improve the ADME profile and remove residual agonism led to the discovery of 12, a potent full antagonist with greater oral bioavailability. Improvements in the ADME profile were realized by designing more ligand-efficient mols. with reduced mol. weights and lower lipophilicities.
Bioorganic & Medicinal Chemistry Letters published new progress about 55376-31-3. 55376-31-3 belongs to alcohols-buliding-blocks, auxiliary class Polymerization Reagents,ATRP Initiators, name is 2-Bromo-2-methylpropan-1-ol, and the molecular formula is C4H9BrO, COA of Formula: C4H9BrO.
Referemce:
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