Baldoneschi, Veronica published the artcileActive-Site Targeting Paramagnetic Probe for Matrix Metalloproteinases, Application In Synthesis of 87905-98-4, the main research area is ytterbium lanthanum complex paramagnetism active site matrix metalloproteinase MMP12; DOTA; inhibitors; lanthanides; metalloproteins; molecular probes.
The design and synthesis of the Ln3+ complexes of a DOTA-containing (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) inhibitor of matrix metalloproteinases are reported. The tight binding of the sulfonamide scaffold to the catalytic domain of the investigated matrix metalloproteinase is not impaired by the presence of the Ln3+-DOTA moiety. The paramagnetic properties of the Ln3+ complex are exploited to obtain insights into the structural features of the ligand-protein interactions and to evaluate the influence of the linker length on the quality of the paramagnetic restraints.
ChemPlusChem published new progress about Complexation. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Application In Synthesis of 87905-98-4.
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