Fuse, Shinichiro published the artcileDesign and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A, Application In Synthesis of 92093-23-7, the main research area is aryldioxaspirodecadienone spiromamakone A analog preparation antitumor activity; Anticancer agent; IXNMJGORXMJZOQ-KGLIPLIRSA-N; Spiroacetal; Spirocycle; Spiromamakone A; Spiropreussione B.
The spirocycle is a key structure found in many bioactive compounds From the cytotoxic and spirocyclic natural product, spiromamakone A (I) and its analogs, a more synthetically accessible spiroacetal template was designed based on structural similarity anal. A total of 50 compounds were rapidly synthesized in only one or two synthetic steps from the starting compound, and their cytotoxicity was evaluated. As a result, (±)-(2R*,5R*)-2-(4-iodophenyl)-7-chloro-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-one (II) was discovered and found to be fifteen-fold more cytotoxic than I. The easily accessible spiroacetal II appeared to act in a manner similar to the highly oxidized natural product, spiromamakone A (I).
European Journal of Medicinal Chemistry published new progress about Antitumor agents. 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Application In Synthesis of 92093-23-7.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts