Hallucinogens. IV. Synthesis of 2,5-dimethoxy-4-methylamphetamine was written by Ono, Masako;Shimamine, Mochihiko;Takahashi, Kazunori. And the article was included in Eisei Shikensho Hokoku in 1973.Related Products of 52010-89-6 The following contents are mentioned in the article:
2,5-Dimethoxy-4-methylamphetamine (I) was prepared The J. C. Duff method was improved to give 2-hydroxy-4-methylbenzaldehyde from m-cresol and hexamine; the reaction temperature was 140°. 2,5-Dihydroxy-4-methylbenzaldehyde (II) was obtained by the J. Renz method and methylation of II with Me2SO4 in alk. solution afforded 2,5-dimethoxy-4-methylbenzaldehyde (III). Reaction of III with EtNO2 in the presence of AcONH4 gave 1-(2,5-dimethoxy-4-methylphenyl)-2-nitropropene (IV). Reduction of IV with LiAlH4 afforded I and its hydrochloride. This study involved multiple reactions and reactants, such as 2,5-Dihydroxy-4-methylbenzaldehyde (cas: 52010-89-6Related Products of 52010-89-6).
2,5-Dihydroxy-4-methylbenzaldehyde (cas: 52010-89-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 52010-89-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts