Molecular docking study, synthesis and evaluation of antitumor activity of novel pyrazole derivatives was written by Jebastin, J. Nelson Samuel;Kumar, T. Ramesh;Evangelin, D.. And the article was included in International Journal of Pharmaceutical and Chemical Sciences in 2016.HPLC of Formula: 52010-89-6 The following contents are mentioned in the article:
A series of (benzylideneamino)phenyl-1H-pyrazol-3(2H)-one derivatives I [R = 3-Me, 3,6-(OH)2, 2,4,6-(NH2)3, etc.] was synthesized via condensation of 4-aminoantipyrine with benzaldehydes. All the synthesized compounds were evaluated for for their ability to inhibit cell proliferation in cancer cell lines and tested in silico for their interaction with histone deacetylase (HDAC8) enzyme. Based on the docking score, compound I [R = 3-Br-6-OH] showed highest docking score of -6.4061, which is important for HDAC8 inhibition. Among the synthesized compounds, compound I [R = 3-Br-6-OH] showed promising activity against human cervical cancer cell line. This study involved multiple reactions and reactants, such as 2,5-Dihydroxy-4-methylbenzaldehyde (cas: 52010-89-6HPLC of Formula: 52010-89-6).
2,5-Dihydroxy-4-methylbenzaldehyde (cas: 52010-89-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.HPLC of Formula: 52010-89-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts