HPLC of Formula: 7748-36-9In 2020 ,《Cu(II)-catalyzed sulfonylation of 7-azaindoles using DABSO as SO2-Source and its mechanistic study》 was published in Tetrahedron. The article was written by Urvashi; Dar, Mohammad Ovais; Bharatam, Prasad V.; Das, Parthasarathi; Kukreti, Shrikant; Tandon, Vibha. The article contains the following contents:
DABSO mediated sulfonylation of iodinated 7-azaindoles I [R = H, Cl; R1 = H, Br, 4-methoxyphenyl, 2-(4-methylphenyl)ethynyl; R2 = H, Cl, OMe, ; R3 = H, 4-methoxyphenyl] was achieved for the first time through sulfonylative Suzuki-Miyaura cross coupling (SMC) reaction under mild conditions giving good yields of sulfonylated 7-azaindole derivatives II (R4 = 3,4,5-trimethoxyphenyl, pyridin-4-yl, naphthalen-1-yl, etc.). Interestingly, control experiments suggest that present method involves in-situ generation of ArSO2 free radical followed by the key steps of SMC reaction. Scope of the reaction was explored with both electronically different and bulky group carrying boronic acids ArB(OH)2 as coupling partner. The sulfonylation is scalable and occurred selectively at iodo group, irresp. of its position on azaindole. Moreover, the proposed mechanism has been supported by ESR (EPR) and d. functional theory (DFT) calculations In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9HPLC of Formula: 7748-36-9)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.HPLC of Formula: 7748-36-9
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