In 2022,Podjed, Nina; Modec, Barbara published an article in Molecules. The title of the article was 《Hydrogen Bonding and Polymorphism of Amino Alcohol Salts with Quinaldinate: Structural Study》.Synthetic Route of C3H9NO The author mentioned the following in the article:
Three amino alcs., 3-amino-1-propanol, 2-amino-1-butanol and 2-amino-2-methyl-1-propanol were reacted with quinoline-2-carboxylic acid, known as quinaldinic acid. This combination yielded three salts, I [R = 3-hydroxypropylammonium, 1-hydroxymethyl propylammonium, 2-hydroxy-1,1-dimethyl-Et ammonium]. The 2-amino-1-butanol and 2-amino-2-methyl-1-propanol systems produced two polymorphs each, labeled as salts I [R = 1-hydroxymethyl propylammonium, 2-hydroxy-1,1-dimethyl-Et ammonium] resp. The compounds were characterized by X-ray structure anal. on single-crystal. The crystal structures of all consisted of protonated amino alcs. with NH3+ moiety and quinaldinate anions with carboxylate moiety. The used amino alcs. contained one OH and one NH2 functional group, both proned to participate in hydrogen bonding. Therefore, similar connectivity patterns were expected. This proved to be true to some extent as all structures contained the NH3+•••-OOC heterosynthon. Nevertheless, different hydrogen bonding and π•••π stacking interactions were observed, leading to distinct connectivity motifs. The largest difference in hydrogen bonding occurred between polymorphs , I [R = 2-hydroxy-1,1-dimethyl-Et ammonium] as they had only one heterosynton in common. In the part of experimental materials, we found many familiar compounds, such as 3-Aminopropan-1-ol(cas: 156-87-6Synthetic Route of C3H9NO)
3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C3H9NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts