In 2019,Molecules included an article by Nakamae, Ikuko; Morimoto, Tsumoru; Shima, Hiroki; Shionyu, Masafumi; Fujiki, Hisayo; Yoneda-Kato, Noriko; Yokoyama, Takashi; Kanaya, Shigehiko; Kakiuchi, Kiyomi; Shirai, Tsuyoshi; Meiyanto, Edy; Kato, Jun-ya. Synthetic Route of C7H6O3. The article was titled 《Curcumin derivatives verify the essentiality of ROS upregulation in tumor suppression》. The information in the text is summarized as follows:
Curcumin has been shown to exert pleiotropic biol. effects, including anti-tumorigenic activity. We previously showed that curcumin controls reactive oxygen species (ROS) levels through the ROS metabolic enzymes, to prevent tumor cell growth. In this study, we synthesized 39 novel curcumin derivatives and examined their anti-proliferative and anti-tumorigenic properties. Thirty-nine derivatives exhibited anti-proliferative activity toward human cancer cell lines, including CML-derived K562 leukemic cells, in a manner sensitive to an antioxidant, N-acetyl-cysteine (NAC). Some compounds exhibited lower GI50 values than curcumin, some efficiently induced cell senescence, and others markedly increased ROS levels, efficiently induced cell death and suppressed tumor formation in a xenograft mouse model, without any detectable side effects. A clustering anal. of the selected compounds and their measurement variables revealed that anti-tumorigenic activity was most well-correlated with an increase in ROS levels. Pulldown assays and a mol. docking anal. showed that curcumin derivatives competed with co-enzymes to bind to the resp. ROS metabolic enzymes and inhibited their enzymic activities. The anal. of novel curcumin derivatives established the importance of ROS upregulation in suppression of tumorigenesis, and these compounds are potentially useful for the development of an anti-cancer drug with few side effects. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Synthetic Route of C7H6O3)
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Synthetic Route of C7H6O3
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