The author of 《Synthesis of Chiral Triazole-Based Halogen Bond Donors》 were Kaasik, Mikk; Kaabel, Sandra; Kriis, Kadri; Jarving, Ivar; Kanger, Tonis. And the article was published in Synthesis in 2019. Application In Synthesis of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The author mentioned the following in the article:
The simple click chem. was applied for the straightforward synthesis of enantiomerically pure mono- and bidentate as well as multifunctional iodotriazole-based halogen bond donors I [R1 = (R,R)-2-acylaminocyclohexyl, acyl = MeCO, t-BuCO, PhCO, R2 = Ph; R1 = (1S,2R)-2-hydroxyindenyl, L-menthyl; R2 = 3,5-(F3C)2C6H3; etc.] and II. The methodol. is characterized by a wide variability due to easy access to chiral azides. In addition to this study using (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol, there are many other studies that have used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Application In Synthesis of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol) was used in this study.
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Application In Synthesis of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol
Referemce:
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Alcohols – Chemistry LibreTexts