In 2018,Meng, Fei-Fan; Xie, Jia-Hao; Xu, Yun-He; Loh, Teck-Peng published ãCatalytically asymmetric synthesis of 1,3-bis(silyl)propenes via copper-catalyzed double proto-silylations of polar enynesã?ACS Catalysis published the findings.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:
A copper-catalyzed (CuCl2/bpy) double proto-silylations of electron-deficient conjugated enynes RCH:CHCCX (X = CO2Me, CN, COCH2CH2Ph) with silylboronate PhMe2SiBpin to synthesize functional bis(silyl)propenes (E)-RCH(SiMe2Ph)CH:C(SiMe2Ph)CH2X (3; R = aryl, alkyl, thienyl) was developed. Under mild reaction conditions, the silylboronate PhMe2Si-Bpin reacts with the enynes via cascade proto-silylations and yields the corresponding Z-specific bis(silyl)propene products in up to 98% yield and 95% ee. In addition, the use instead of bipyridines chiral enantiopure substituted and annelated 2-pyridyloxazoles resulted in enantioselective synthesis of the compounds (3) was also achieved. In the experiment, the researchers used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (RâCâ¡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CHâNHRâ? to form imines (R2C=NRâ?. Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol
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