In 2022,Yeung, Jason; Becker, Matthias; Stephan, Douglas W. published an article in Dalton Transactions. The title of the article was 《Towards macrocyclic frustrated Lewis pairs》.Safety of 2,6-Pyridinedimethanol The author mentioned the following in the article:
Macrocycles with and without B-N bonds were prepared from reaction of C6F5BH2·SMe2 or MesBH2 with the 2,6-pyridinedimethanol derivatives Both classes of macrocycle reacted with B(C6F5)3 but were unreactive to small mols. These observations provide insights for the subsequent design of macrocyclic FLPs for multi-electron reactions. After reading the article, we found that the author used 2,6-Pyridinedimethanol(cas: 1195-59-1Safety of 2,6-Pyridinedimethanol)
2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 2,6-Pyridinedimethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts