Maji, Milan; Borthakur, Ishani; Guria, Saikat; Singha, Suman; Kundu, Sabuj published their research in Journal of Catalysis in 2021. The article was titled 《Direct access to 2-(N-alkylamino)pyrimidines via ruthenium catalyzed tandem multicomponent annulation/N-alkylation》.Recommanded Product: 100-55-0 The article contains the following contents:
A new cooperative ruthenium complex catalyzed tandem multicomponent synthesis of 2-(N-alkylamino)pyrimidines I [R = Ph, 4-MeOC6H4; R1 = 4-MeC6H4, 4-BrC6H4, 2-thienyl, etc.; R2 = H, Me; R3 = Ph, 4-FC6H4, cyclohexyl, etc.; R2R3 = (CH2)5] directly from guanidine salt and alcs. was developed. The reactions proceeded through the dehydrogenation of alcs., followed by C-C coupling and sequential C-N coupling with guanidine and primary alc., with the elimination of three equivalent of hydrogen gas. In this work, application of both the acceptorless dehydrogenative coupling (ADC) and borrowing hydrogen (BH) strategies were accomplished in a single reaction. This catalytic method tolerated a wide range of substrates. The viability of the current method was demonstrated by preparative scale synthesis of a few products. A plausible catalytic cycle was proposed based on various control experiments, mechanistic studies and DFT calculations Remarkably, 42 new 2-(N-alkylamino)pyrimidines were synthesized following this catalytic protocol. The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 100-55-0)
3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 100-55-0
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