Ludwig, Jacob R.; Simmons, Eric M.; Wisniewski, Steven R.; Chirik, Paul J. published their research in Organic Letters in 2021. The article was titled 《Cobalt-Catalyzed C(sp2)-C(sp3) Suzuki-Miyaura Cross Coupling》.Application of 24388-23-6 The article contains the following contents:
A cobalt-catalyzed method for the C(sp2)-C(sp3) Suzuki-Miyaura cross coupling of aryl boronic esters and alkyl bromides is described. Cobalt-ligand combinations were assayed with high-throughput experimentation, and cobalt(II) sources with trans-N,N’-dimethylcyclohexane-1,2-diamine (DMCyDA, L1) produced optimal yield and selectivity. The scope of this transformation encompassed steric and electronic diversity on the aryl boronate nucleophile as well as various levels of branching and synthetically valuable functionality on the electrophile. Radical trap experiments support the formation of electrophile-derived radicals during catalysis. The experimental process involved the reaction of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Application of 24388-23-6)
4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Application of 24388-23-6
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