Vaillant, Fabrice; Corrales-Agudelo, Vanesa; Moreno-Castellanos, Natalia; Angel-Martin, Alberto; Henao-Rojas, Juan Camilo; Munoz-Durango, Katalina; Poucheret, Patrick published an article in 2021, the title of the article was Plasma Metabolome Profiling by High-Performance Chemical Isotope-Labelling LC-MS after Acute and Medium-Term Intervention with Golden Berry Fruit (Physalis peruviana L.), Confirming Its Impact on Insulin-Associated Signaling Pathways.Electric Literature of 621-37-4 And the article contains the following content:
Golden berry (Physalis peruviana L.) is an exotic fruit exported from Colombia to different countries around the world. A review of the literature tends to demonstrate a hypoglycemic effect with an improvement in insulin sensitivity after oral ingestion of fruit extracts in animal models. However, little is known about their potential effects in humans, and very little is known about the mechanisms involved. This study aimed at identifying discriminant metabolites after acute and chronic intake of golden berry. An untargeted metabolomics strategy using high-performance chem. isotope-labeling LC-MS was applied. The blood samples of eighteen healthy adults were analyzed at baseline, at 6 h after the intake of 250 g of golden berry (acute intervention), and after 19 days of daily consumption of 150 g (medium-term intervention). Forty-nine and 36 discriminant metabolites were identified with high confidence, resp., after the acute and medium-term interventions. Taking into account up- and downregulated metabolites, three biol. networks mainly involving insulin, epidermal growth factor receptor (EGFR), and the phosphatidylinositol 3-kinase pathway (PI3K/Akt/mTOR) were identified. The biol. intracellular networks identified are highly interconnected with the insulin signalling pathway, showing that berry intake may be associated with insulin signalling, which could reduce some risk factors related to metabolic syndrome. Primary registry of WHO. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Electric Literature of 621-37-4
The Article related to diet supplement physalis plasma metabolome insulin egfr putrescine vitamina, physalis peruviana, insulin, metabolomic, nutritional intervention, Animal Nutrition: Other and other aspects.Electric Literature of 621-37-4
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