Ono, Kenjiro; Tsuji, Mayumi; Yamasaki, Tritia R.; Pasinetti, Giulio M. published an article in 2020, the title of the article was Anti-aggregation effects of phenolic compounds on 伪-synuclein.SDS of cas: 621-37-4 And the article contains the following content:
A review. The aggregation and deposition of 伪-synuclein (伪S) are major pathol. features of Parkinson’s disease, dementia with Lewy bodies, and other 伪-synucleinopathies. The propagation of 伪S pathol. in the brain plays a key role in the onset and progression of clin. phenotypes. Thus, there is increasing interest in developing strategies that attenuate 伪S aggregation and propagation. Based on cumulative evidence that 伪S oligomers are neurotoxic and critical species in the pathogenesis of 伪-synucleinopathies, we and other groups reported that phenolic compounds inhibit 伪S aggregation including oligomerization, thereby ameliorating 伪S oligomer-induced cellular and synaptic toxicities. Heterogeneity in gut microbiota may influence the efficacy of dietary polyphenol metabolism Our recent studies on the brain-penetrating polyphenolic acids 3-hydroxybenzoic acid (3-HBA), 3,4-dihydroxybenzoic acid (3,4-diHBA), and 3-hydroxyphenylacetic acid (3-HPPA), which are derived from gut microbiota-based metabolism of dietary polyphenols, demonstrated an in vitro ability to inhibit 伪S oligomerization and mediate aggregated 伪S-induced neurotoxicity. Addnl., 3-HPPA, 3,4-diHBA, 3-HBA, and 4-hydroxybenzoic acid significantly attenuated intracellular 伪S seeding aggregation in a cell-based system. This review focuses on recent research developments regarding neuroprotective properties, especially anti-伪S aggregation effects, of phenolic compounds and their metabolites by the gut microbiome, including our findings in the pathogenesis of 伪-synucleinopathies. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4
The Article related to review phenolics anti aggregation alpha synuclein neurotoxicity, parkinson鈥檚 disease, gut microbiome, phenolic compounds, 伪-synuclein, Toxicology: Reviews and other aspects.SDS of cas: 621-37-4
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