On August 30, 1956, Abe, Kyuji published a patent.Electric Literature of 62640-03-3 The title of the patent was Monoalkylaminoethanols. And the patent contained the following:
Hydroxyethylsaccharin (11.3 g.) is boiled with 25 cc. 20% NaOH solution 10 min., 16.5 g. Me2SO4 added, and warmed at 50-60掳 1 hr. to afford sirupy N-methyl-N-(hydroxyethyl)-慰-carboxybenzenesulfonamide (I). I is boiled with NaOH solution prepared from 4.4 g. NaOH, 13 cc. H2O, and 20 cc. alc. 1 hr., slightly acidified by dilute HCl, the alc. evaporated in vacuo, heated with 20 cc. 10% HCl 2 hrs., cooled, made alk. by NaOH, distilled with steam, the product caught in dilute HCl, evaporated, and dried to afford 72% monomethylaminoethanol hydrochloride, hygroscopic crystals; picrate, m. 146-7掳. Similarly were prepared monoethylaminoethanol hydrochloride, hygroscopic crystals (picrate, m. 125-6掳); and monomethylaminoethyl Ph ether hydrochloride, m. 174-5掳. These are useful as starting materials for antihistaminic drugs. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Electric Literature of 62640-03-3
2-(Methylamino)ethan-1-ol hydrochloride(cas:62640-03-3) belongs to alcohols. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Electric Literature of 62640-03-3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts