Myerson, Jacob W.; Patel, Priyal N.; Rubey, Kathryn M.; Zamora, Marco E.; Zaleski, Michael H.; Habibi, Nahal; Walsh, Landis R.; Lee, Yi-Wei; Luther, David C.; Ferguson, Laura T.; Marcos-Contreras, Oscar A.; Glassman, Patrick M.; Mazaleuskaya, Liudmila L.; Johnston, Ian; Hood, Elizabeth D.; Shuvaeva, Tea; Wu, Jichuan; Zhang, Hong-Ying; Gregory, Jason V.; Kiseleva, Raisa Y.; Nong, Jia; Grosser, Tilo; Greineder, Colin F.; Mitragotri, Samir; Worthen, George S.; Rotello, Vincent M.; Lahann, Joerg; Muzykantov, Vladimir R.; Brenner, Jacob S. published an article on January 31 ,2022. The article was titled 《Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation》, and you may find the article in Nature Nanotechnology.Application In Synthesis of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate The information in the text is summarized as follows:
This study shows that the supramol. arrangement of proteins in nanoparticle structures predicts nanoparticle accumulation in neutrophils in acute lung inflammation (ALI). We observed homing to inflamed lungs for a variety of nanoparticles with agglutinated protein (NAPs), defined by arrangement of protein in or on the nanoparticles via hydrophobic interactions, crosslinking and electrostatic interactions. Nanoparticles with sym. protein arrangement (for example, viral capsids) had no selectivity for inflamed lungs. Flow cytometry and immunohistochem. showed NAPs have tropism for pulmonary neutrophils. Protein-conjugated liposomes were engineered to recapitulate NAP tropism for pulmonary neutrophils. NAP uptake in neutrophils was shown to depend on complement opsonization. We demonstrate diagnostic imaging of ALI with NAPs; show NAP tropism for inflamed human donor lungs; and show that NAPs can remediate pulmonary edema in ALI. This work demonstrates that structure-dependent tropism for neutrophils drives NAPs to inflamed lungs and shows NAPs can detect and treat ALI. In the experiment, the researchers used 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Application In Synthesis of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate)
2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Application In Synthesis of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate
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