On December 25, 1991, Nakada, Masanori; Inoue, Shintaro; Tonomura, Mikio published a patent.Computed Properties of 62640-03-3 The title of the patent was Ethanolamine derivatives for treatment of diseases accompanied by excessive collagen accumulation. And the patent contained the following:
R1NR2CHR3CH2OH (R1, R2 = H, Me; R3 = H, Me, Et; R1 = R2 = R3 ≠ H) or their pharmacol. acceptable salts are useful for treatment of diseases, such as hepatic fibrosis (including cirrhosis and chronic hepatitis), pulmonary fibrosis, keloid, scleroderma, etc. An aqueous 600 μM N-methylethanolamine (I) solution (2 mL) was added to a 2 mL a medium containing human HT-P11 fibrosarcoma cells to show 224% promotion of procollagenase production by the cells. Rats with hepatic fibrosis were administered p.o. with an aqueous 66.6 mg I/mL solution at 3 mL/kg/day for 7 wk to show serum levels of glutamic-pyruvic transaminase 436, glutamic-oxaloacetic transaminase 1250, and γ-glutamyl transpeptidase 7.0 U/L, vs. 948, 2170, and 17.6 U/L, resp., for controls without administration of I. I also lowered the serum levels of total bilirubin, alk. phosphatase, thymol turbidity, and ZnSO4 turbidity. I at 2 g/kg p.o. showed no mortality in mice. Tablets (200 mg each) containing I.HCl 50, lactose 10, corn starch 30, crystalline cellulose 8, hydroxypropyl cellulose 1, and Mg stearate 1 g were formulated. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Computed Properties of 62640-03-3
The Article related to liver lung fibrosis treatment ethanolamine, cirrhosis hepatitis treatment ethanolamine, scleroderma treatment procollagenase production ethanolamine, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 62640-03-3
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