Zhou, Dejian; Li, Peipei; Dong, Zhe; Wang, Teng; Sun, Kunlai; Zhao, Yuqin; Wang, Bin; Chen, Yin published the artcile< Structure and immunoregulatory activity of β-D-galactofuranose-containing polysaccharides from the medicinal fungus Shiraia bambusicola>, SDS of cas: 3458-28-4, the main research area is galactofuranose polysaccharide immunoregulation macrophage Shiraia; Galactofuranose; Macrophages; Medical fungi; Polysaccharide; Structure.
To explore bioactive polysaccharides from medicinal fungi, a homogeneous heteropolysaccharide SB1-1 was extracted from the stroma of Shiraia bambusicola by enzyme assisted extraction, ethanol precipitation, anion-exchange and size-exclusion chromatogs. Chem. and spectroscopic analyses showed that SB1-1 was a neutral polysaccharide composed of mannose, glucose and galactose at a molar ratio of 1.1:1.9:1.0, and had a mol. weight of 18.3 kDa. SB1-1 was composed of a mannan core and glucose and galactose side chains. The mannan core was composed of (1 → 2)-α-Manp substituted by the side chains (1 → 6)-α-D-Manp, (1 → 4)- α-D-Glcp and (1 → 6)-α-D-Glcp with different ds.p. at the C-6. The galactose side chains had the backbone of (1 → 6)-β-D-Galf. There were two branch sites on every five sugars on average at the O-2 of →6)-β–Galf(1→, and the branches consisted of (→2)-β-D-Galf(1→ and terminal β-D-Galf) 1→. The potential immunomodulatory activities of SB1-1 on RAW264.7 macrophages were investigated. The results showed that SB1-1 could activate macrophage and significantly improve its phagocytic ability by neutral red uptake assay. Addnl., SB1-1 enhanced the productions of IL-1, IL-6, IL-12 and TNF-α in the RAW264.7 macrophages by stimulation of SB1-1, while significantly increased the production of inducible nitric oxide synthase (iNOS) production This study demonstrated that the galactofuranose-containing polysaccharide SB1-1 from S. bambusicola which is a novel mannogalactoglucan, could enhance the activation of macrophages.
International Journal of Biological Macromolecules published new progress about Acid hydrolysis. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, SDS of cas: 3458-28-4.
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