Wikberg, Martin; Alderborn, Goeran published the artcile< Compression characteristics of granulated materials. IV. The effect of granule porosity on the fragmentation propensity and the compactibility of some granulations>, Application of C14H8N2Na2O6, the main research area is granulation granule porosity fragmentation compactibility; compression granulation tablet property.
Eleven granulations of a common filler (lactose) and 3 granulations of a high-dosage drug (dipentum) were produced by wet granulation with poly(vinylpyrrolidone) as binder in a high shear mixer. The agglomeration process was varied to produce granulations with varying granule porosity. The size fraction 500-710 μm was separated and characterized on binder content (lactose granulations), granule porosity and friability. The granule fragmentation during compaction was evaluated by measurements of the air permeability of the tablets. Finally, the diametral compression strength of tablets compacted from unlubricated granulations and lactose granulations lubricated with 0.5% by weight magnesium stearate at 150 MPa was measured. The results showed that the degree of granule fragmentation during compaction was related to the granule porosity before compaction. A granulation with a higher porosity had a higher fragmentation propensity, as evaluated by the permeametry measurements, and the tablet strength was less affected by magnesium stearate addition The tablet strength correlated well with the degree of fragmentation, i.e. a granulation with higher degree of fragmentation gave tablets of a higher mech. strength. Variations in compactibility, when the same formulation is wet granulated under different process conditions, can be explained by variations in granule porosity.
International Journal of Pharmaceutics published new progress about Pharmaceutical granules. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application of C14H8N2Na2O6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts