Su, Lebin; Xie, Shimin; Dong, Jianyu; Liu, Feng; Yin, Shuang-Feng; Zhou, Yongbo published the artcile< Copper-Catalyzed Nitrogen Atom Transfer to Isoquinolines via C-N Triple Bond Cleavage and Three-Component Cyclization>, Name: (4-Ethynylphenyl)methanol, the main research area is bromoaryl ketone alkyne acetonitrile copper catalyst three component cyclization; isoquinoline preparation.
A copper(I)-catalyzed tandem reaction of 2-bromoaryl ketones, terminal alkynes, and CH3CN was developed, which combines N atom transfer and three-component [3 + 2 + 1] cyclization, and efficiently produces densely functionalized isoquinolines in a facile, highly selective, and general manner. In the reaction, the formation of aromatic C-N bonds along with the complete C-N triple bond cleavage was first realized; Cu(III)-acetylide species might serve as the intermediates, which allow highly selective 6-endo-dig cyclization.
Organic Letters published new progress about Alkynes, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Name: (4-Ethynylphenyl)methanol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts