Maines, Lynn W.; Fitzpatrick, Leo R.; Green, Cecelia L.; Zhuang, Yan; Smith, Charles D. published the artcile< Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease>, COA of Formula: C14H8N2Na2O6, the main research area is sphingosine kinase inhibitor ABC294640 colon edema cytokine Crohns disease.
Aim: Activation of sphingosine kinase (SK) is a key response to many inflammatory processes. The present studies test the hypothesis that an orally available SK inhibitor, ABC294640, would be effective in rodent models of Crohn’s disease. Methods: Trinitrobenzene sulfonic acid (TNBS) was administered rectally to mice and rats. Rats were treated with ABC294640 orally alone or in combination with olsalazine and disease progression was monitored. Results: For both rodent species, treatment with ABC294640 attenuated disease progression. Colon samples from the ABC294640-treated animals had improved histol. and cytokine parameters when compared with vehicle-treated animals. The expression of SK was similarly increased in TNBS-treated animals and in human colon tissue specimens from inflammatory bowel disease patients relative to normal, control patients. Conclusions: Sphingosine kinase may be a critical mediator of colonic damage during intestinal inflammation, and pharmacol. inhibitors of this enzyme may prove useful in the treatment of Crohn’s disease.
Inflammopharmacology published new progress about Body weight. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, COA of Formula: C14H8N2Na2O6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts