Gvozdev, V. D.; Shavrin, K. N.; Nefedov, O. M. published the artcile< A new synthesis of bicyclic N,O- and N,S-enaminals by the anionic cyclization of alk-4-ynals with amino alcohols and amino thiols>, Computed Properties of 45434-02-4, the main research area is arylmethylene pyrrolooxazine pyrrolooxazole pyrrolothiazole stereoselective preparation; bicyclic enaminal stereoselective preparation; base mediated cyclocondensation amino alc thiol alkynal.
4-Alkynals RCCCH2CR1R2CHO [R = Ph, 2-thienyl, 4-F3CC6H4; R1 = R2 = H, Me; R1R2 = (CH2)5] underwent base-mediated cyclocondensations with amino alcs. H2NCH2XCH2OH (X = bond, Me2C, 1,1-cyclopropanediyl) or 2-aminoethanethiol hydrochloride with KOH in DMSO to yield arylmethylene pyrrolooxazines, pyrrolooxazoles, and pyrrolothiazoles I [R = Ph, 2-thienyl, 4-F3CC6H4; R1 = R2 = H, Me; R1R2 = (CH2)5; X = bond, Me2C, 1,1-cyclopropanediyl; Y = O, S] (bicyclic enaminals) stereoselectively as the (E)-isomers in 30-82% yields.
Russian Chemical Bulletin published new progress about Alkynals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (aryl). 45434-02-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C5H11NO, Computed Properties of 45434-02-4.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts