《Highly selective anti-Prelog synthesis of optically active aryl alcohols by recombinant Escherichia coli expressing stereospecific alcohol dehydrogenase》 was published in Preparative Biochemistry & Biotechnology in 2016. These research results belong to Li, Ming; Nie, Yao; Mu, Xiao Qing; Zhang, Rongzhen; Xu, Yan. Product Details of 133082-13-0 The article mentions the following:
A recombinant Escherichia coli system expressing anti-Prelog stereospecific alc. dehydrogenase from Candida parapsilosis was established as a whole-cell system for catalyzing asym. reduction of aryl ketones to anti-Prelog configured alcs. Using 2-hydroxyacetophenone as the substrate, reaction factors including pH, cell status, and substrate concentration had obvious impacts on the outcome of whole-cell biocatalysis, and xylose was found to be an available auxiliary substrate for intracellular cofactor regeneration, by which (S)-1-phenyl-1,2-ethanediol was achieved with an optical purity of 97%e.e. and yield of 89% under the substrate concentration of 5 g/L. Addnl., the feasibility of the recombinant cells toward different aryl ketones was investigated, and most of the corresponding chiral alc. products were obtained with an optical purity over 95%e.e. Therefore, the whole-cell system involving recombinant stereospecific alc. dehydrogenase was constructed as an efficient biocatalyst for highly enantioselective anti-Prelog synthesis of optically active aryl alcs. and would be promising in the pharmaceutical industry. In the experiment, the researchers used (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Product Details of 133082-13-0)
(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Product Details of 133082-13-0 Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts