de Beer, Roseri J. A. C.; Boegels, Berry; Schaftenaar, Gijs; Zarzycka, Barbara; Quaedflieg, Peter J. L. M.; van Delft, Floris L.; Nabuurs, Sander B.; Rutjes, Floris P. J. T. published the artcile< Enzyme-Specific Activation versus Leaving Group Ability>, COA of Formula: C5H11NO, the main research area is trypsin catalysis dipeptide synthesis substrate preparation leaving group.
Enzyme-specific activation and the substrate mimetics strategy are effective ways to circumvent the limited substrate recognition often encountered in protease-catalyzed peptide synthesis. A key structural element in both approaches is the guanidinophenyl (OGp) ester, which enables important interactions for affinity and recognition by the enzyme; at least, this is usually the explanation given for its successful application. In this study we show that leaving group ability is of equal or even greater importance. To this end we used both exptl. and computational methods to examine: (1) synthesis of close analogs of OGp, and their evaluation in a dipeptide synthesis assay with trypsin, (2) mol. docking studies to provide insights into the binding mode, and (3) ab initio calculations to evaluate their electronic properties.
ChemBioChem published new progress about Dipeptides Role: BPN (Biosynthetic Preparation), BIOL (Biological Study), PREP (Preparation) (synthesis). 45434-02-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C5H11NO, COA of Formula: C5H11NO.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts