Walko, Martin; Hewitt, Eric; Radford, Sheena E.; Wilson, Andrew J. published the artcile< Design and synthesis of cysteine-specific labels for photo-crosslinking studies>, Electric Literature of 25055-82-7, the main research area is diazirine photocrosslinking reagent crosslinking mass spectrometry.
Chem. crosslinking mass-spectrometry (XL-MS) represents a powerful methodol. to map ligand/biomacromol. interactions, particularly where conventional methods such as X-ray crystallog., NMR (NMR) spectroscopy or cryo-electron microscopy (EM) are not feasible. In this manuscript, we describe the design and synthesis of two new photo-crosslinking reagents that can be used to specifically label free thiols through either maleimido or methanethiosulfonate groups and facilitate PXL-MS workflows. Both crosslinkers are based on light sensitive diazirines – precursors of highly reactive carbenes which offer addnl. advantages over alternative crosslinking groups such as benzophenones and aryl nitrenes given the controlled rapid and more indiscriminate reactivity.
RSC Advances published new progress about Biomacromolecular compounds Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, Electric Literature of 25055-82-7.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts