The author of 《Crystal structures of (E)-3-(4-hydroxybenzylidene)chroman-4-one and (E)-3-(3-hydroxybenzylidene)-2-phenylchroman-4-one》 were Suchojad, Kamil; Dolega, Anna; Adamus-Grabicka, Angelika; Budzisz, Elzbieta; Malecka, Magdalena. And the article was published in Acta Crystallographica, Section E: Crystallographic Communications in 2019. Safety of 3-Hydroxybenzaldehyde The author mentioned the following in the article:
The synthesis and crystal structures of (E)-3-(4-hydroxybenzylidene)chroman-4-one, C16H12O3, I, and (E)-3-(3-hydroxybenzylidene)-2-phenylchroman-4-one, C22H16O3, II, are reported. These compounds are of interest with respect to biol. activity. Both structures display intermol. C-H···O and O-H···O hydrogen bonding, forming layers in the crystal lattice. The crystal structure of compound I is consolidated by π-π interactions. The lipophilicity (logP) was determined as it is one of the parameters qualifying compounds as potential drugs. The logP value for compound I is associated with a larger contribution of C···H interaction in the Hirshfeld surface.3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde) was used in this study.
3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Safety of 3-Hydroxybenzaldehyde
Referemce:
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Alcohols – Chemistry LibreTexts