Liu, En-Chih;Topczewski, Joseph J. published 《Enantioselective Copper Catalyzed Alkyne-Azide Cycloaddition by Dynamic Kinetic Resolution》. The research results were published in《Journal of the American Chemical Society》 in 2019.Safety of (S)-2-Amino-2-(4-fluorophenyl)ethanol The article conveys some information:
In the presence of [Cu(OTf)]2·PhMe and a nonracemic bis(chlorophenyl)pyridinebis(oxazoline), allylic azides such as I underwent enantioselective azide-alkyne cycloaddition reactions via dynamic kinetic resolution to yield nonracemic allylic triazoles such as II. A nonracemic propargyl alc. and propargyl-substituted natural products underwent enantioselective azide-alkyne cycloaddition reactions in high diastereoselectivities. The azide reactants are potentially explosive and should be handled with care; reaction mixtures should not be worked up with acid to avoid the formation of hydrazoic acid and their wastes should be kept sep. from other organic wastes. The experimental procedure involved many compounds, such as (S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) .
(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Safety of (S)-2-Amino-2-(4-fluorophenyl)ethanol
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts