Research on new synthetic routes about 1787246-78-9

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Wu, Zijun; Li, Fangyi; Wang, Jian published the article 《Intermolecular Dynamic Kinetic Resolution Cooperatively Catalyzed by an N-Heterocyclic Carbene and a Lewis Acid》. Keywords: lactone pyrancarboxylic acid ketone preparation enantioselective synthesis; N-heterocyclic carbene; annulation; dynamic kinetic resolution; lactones; oxidative addition.They researched the compound: (5aS,10bR)-2-(2,6-Diethylphenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1787246-78-9 ).Safety of (5aS,10bR)-2-(2,6-Diethylphenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1787246-78-9) here.

The ubiquitous structure of δ-lactones makes the development of new methods for their enantioselective and stereoselective synthesis an important ongoing challenge. The intermol. dynamic kinetic resolution (DKR) of β-halo-α-keto esters cooperatively catalyzed by an N-heterocyclic carbene and a Lewis acid generates two contiguous stereocenters with remarkable diastereoselectivity through an oxidation/lactonization sequence. Under optimized conditions the synthesis of the target compounds was achieved using (5aS,10bR)-5a,10b-dihydro-2-(2,6-diethylphenyl)-4H,6H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazinium tetrafluoroborate (i.e., NHC, nitrogen-heterocyclic carbene) and scandium triflate as catalyst combination. Starting materials included (2E)-3-phenyl-2-butenal and β-(bromo)-α-(oxo)benzenebutanoic acid esters.

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