The origin of a common compound about 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate

At the same time, in my other blogs, there are other synthetic methods of this type of compound,55357-38-5, 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 55357-38-5, 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C12H21NO4S, blongs to alcohols-buliding-blocks compound. Formula: C12H21NO4S

(R) -1,2-glyceryl distearate-glycerol-3-phosphatidic acid (0.2 g, 0.28 mmol)Was added to 60 mL of dry pyridine,It was heated at 50 0.5h,Then, choline p-toluenesulfonate (0.84 g, 3 mmol)And trichloroacetonitrile 5mL,The reaction was continued at 50 36h,Concentration under reduced pressure crude,Flash column chromatography (developing solvent CHCl3-CH3OH-H2O, 15: 5: 1) gave a white gel, 0.13 g, 59% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,55357-38-5, 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate, and friends who are interested can also refer to it.

Reference:
Patent; Ji, Min; Cai, Jin; Gu, Ning; Li, Rui; (7 pag.)CN103408588; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts