Adding a certain compound to certain chemical reactions, such as: 55977-10-1, 3-Bromo-7-hydroxy-4-methylchromen-2-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks
General procedure: The appropriate 7-hydroxycoumarin 1a-g (2.0 mmol for 2a-gand 2i-r; 3.0 mmol for 1h) was suspended in anhydrous acetone(10 mL) before adding potassium carbonate (for 2a-g and 2i-r: 0.83 g, 6.0 mmol; for 1h: 1.2 g, 9.0 mmol), the suitable monohalide(for 1h: 2-[4-(bromomethyl)phenyl]ethanol, 3.0 mmol) or dihalide(for 2a-g and 2i-r: 6.0 mmol of alpha,alpha’-dibromo(chloro)-xylenes or trans-1,4-dibromo-2-butene; 10 mmol of 1,omega-dibromoalkanes) anda catalytic amount of KI in a Pyrex vessel charged with a magnetic stirring bar and aWeflon bar. The vessel was placed in a microwave apparatus and irradiated at 130 C for 30 min. After cooling to room temperature, the inorganic residue was filtered off after thorough washing with CH2Cl2. The solutionwas concentrated to dryness andthe resulting crude was purified as detailed below.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,55977-10-1, 3-Bromo-7-hydroxy-4-methylchromen-2-one, and friends who are interested can also refer to it.
Reference:
Article; Rullo, Mariagrazia; Niso, Mauro; Pisani, Leonardo; Carrieri, Antonio; Colabufo, Nicola Antonio; Cellamare, Saverio; Altomare, Cosimo Damiano; European Journal of Medicinal Chemistry; vol. 161; (2019); p. 433 – 444;,
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