Application of 18385-82-5, Adding some certain compound to certain chemical reactions, such as: 18385-82-5, name is 7-Bromochroman-4-ol,molecular formula is C9H9BrO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18385-82-5.
To a solution of 7-Bromochroman-4-ol (Prepared as described in U52013/18055)(0.64g, 2.78 mmol), tert-Butyl 4-(2-hydroxy-5-(trifluoromethyl)phenyl)piperidine- 1 -carboxylate (Intermediate-iS) (0.80g, 2.3 16 mmol) and triphenylphosphine (0.91g, 3.47 mmol) in THF (25 ml) was added DIAD (0.901 ml, 4.63 mmol) stined at room temperature for 16h. Reaction mixture was diluted with ethyl actate and washed with aqueous NaOH solution, brine, dried over Na2SO4 and evaporated. The crude product was purified by flash column chromatography( 10% ethyl acetate/Petroleum ether) to obtain title compound(0.5g, 39 %). LCMS(ESI):m/z 578.12 (M+Na).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18385-82-5, 7-Bromochroman-4-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; LUPIN LIMITED; RAMDAS, Vidya; LORIYA, Rajeshkumar, Maganlal; WALKE, Deepak, Sahebrao; DAS, Amit, Kumar; KHAN, Talha, Hussain; BANERJEE, Moloy; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; (187 pag.)WO2015/151001; (2015); A1;,
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