Adding a certain compound to certain chemical reactions, such as: 666747-06-4, (2,4-Dibromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of (2,4-Dibromophenyl)methanol, blongs to alcohols-buliding-blocks compound. Safety of (2,4-Dibromophenyl)methanol
To the solution of (2,4-dibromophenyl)methanol (10.0 g, 37.6 mmol) was added TBSC1 (6.8 g, 45.1 mmol), imidazole (5.1 g, 75.2 mmol). The mixture was stirred at 40 °C overnight. After the reaction completed, the mixture was washed by water and DCM was removed under vacuo. The residue was purified by column chromatography on silica gel by elution with petroleum ether : ethyl acetate =50: 1 to give tert-butyl(2,4-dibromobenzyloxy)dimethylsilane (14 g, yield 98percent) as a light yellow liquid. XH NMR (400 MHz, CDC13) delta 7.68 (d, 1 H), 7.47 (m, 2H), 4.69 (s, 2H), 0.94 (s, 9 H), 0.15 (s, 6 H).
The synthetic route of 666747-06-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ANACOR PHARMACEUTICALS, INC.; BILL AND MELINDA GATES FOUNDATION; LI, Xianfeng; LUNDE, Christopher, S.; JACOBS, Robert, T.; HERNANDEZ, Vincent, S.; XIA, Yi; PLATTNER, Jacob, J.; CAO, Kathy, Jingyuan; ZHANG, Yong-kang; Perry, Matthew; (268 pag.)WO2017/151489; (2017); A1;,
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