An article Retrospective review of Kawasaki disease at the Women’s and Children’s Hospital, South Australia WOS:000656443500001 published article about INTRAVENOUS IMMUNOGLOBULIN TREATMENT; CORONARY-ARTERY ABNORMALITIES; PREDICTION; RESISTANCE; EFFICACY; THERAPY; PREDNISOLONE; PREVENTION; ANEURYSMS; TRIAL in [Davidson, Hannah; Kelly, Andrew] Univ Adelaide, Womens & Childrens Hosp, Dept Cardiol, Adelaide, SA, Australia; [Agrawal, Rishi] Univ Adelaide, Womens & Childrens Hosp, Dept Gen Paediat Med, Adelaide, SA, Australia; [Kelly, Andrew; Agrawal, Rishi] Univ Adelaide, Fac Hlth & Med Sci, Dept Paediat Adelaide, Adelaide, SA, Australia in , Cited 25. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5. Recommanded Product: (4-Methoxyphenyl)methanol
Aim Kawasaki disease (KD) is one of the most common causes of acquired cardiac disease in children in high-income countries. The incidence of coronary artery disease (CAD), despite treatment with intravenous immunoglobulin, ranges from 5 to 20%. Determining risk factors for CAD may assist with management and reduce long-term complications. Methods Retrospective data were collected for all patients presenting to the Women’s and Children’s Hospital with a discharge diagnosis of KD over a 10.5-year period, from 2007 to 2018. Results A total of 141 patients were included in the review; 101 patients fulfilled complete criteria for KD; 25 incomplete criteria and 15 did not meet criteria but were treated for KD. CAD was present in 27.7% of all patients, ranging from ectasia to giant aneurysms based on Z-scores and echocardiogram descriptions. Medium to large aneurysms accounted for 8.5% of all patients with suspected KD. Patients with CAD were more likely to: fulfil incomplete criteria (odds ratio (OR) 4.3, 95% confidence interval (CI) 1.7-10.8, P = 0.0027), be less than 12 months of age (OR 11.38, 95% CI 2.94-44.11, P = 0.0001), have CRP > 100 (OR 2.8, 95% CI 1.31-6.02, P = 0.0068) and have a delay in treatment (average day of illness prior to treatment 8.89 vs. 6.78 (OR 1.19, 95% CI 1.05-1.35, P = 0.0055)). Patients with a Kobayashi score >= 4 had a higher rate of re-treatment with intravenous immunoglobulin (OR 3.16, 95% CI 1.27-7.83, P = 0.013). Conclusion Our data are consistent with previously reported risk factors, and high rates of CAD despite standard treatment.
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