The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 149965-40-2, name is (5-Bromo-2-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 149965-40-2
(5-Bromo-2-chloro-benzyloxy)-tert-butyl-dimethyl-silane.TBDMS-Cl (10.6 g, 66.7 mmol) was added to a sol. of (5-bromo-2-chloro-phenyl)- methanol (12.8 g, 55.6 mmol) and imidazole (9.42 g, 138 mmol) in DMF (190 mL) at 0 0C. The mixture was stirred for 2 h at 0 0C, and aq. sat. NH4Cl was added. The mixture was extracted with heptane (2x). The combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Purification of the residue by FC (heptane ? EtOAc/heptane 1 :49) yielded the title compound (18.0 g, 96%). LC-MS: tR = 1.22 min.
With the rapid development of chemical substances, we look forward to future research findings about 149965-40-2.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2007/88514; (2007); A1;,
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