Application of 480449-99-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.480449-99-8, name is Benzyl 3-hydroxycyclobutanecarboxylate, molecular formula is C12H14O3, molecular weight is 206.24, as common compound, the synthetic route is as follows.
To a solution of the compound obtained in Referential Example 151 (317 mg) in N,N-dimethylformamide (3.0 mL) were added methyl iodide (194 muL) and silver oxide (237 mg), followed by stirring at 45C for 1 hour. To the reaction mixture were added additional methyl iodide (194 muL) and silver oxide (226 mg), followed by stirring at 45C for 16 hours. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate : hexane = 1:10), to thereby give the title compound (152 mg).1H-NMR(CDCl3) delta:2.14-2.24(2H, m), 2.44-2.54(2H, m), 2.59-2.72(1H, m), 3.21(3H, s), 3.73-3.81(1H, m), 5.11(2H, s), 7.22-7.39(5H, m). MS(ESI)m/z:221(M+H+).
Statistics shows that 480449-99-8 is playing an increasingly important role. we look forward to future research findings about Benzyl 3-hydroxycyclobutanecarboxylate.
Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1577301; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts